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Genome Information for Mus musculus
The pre-B cell receptor (pre-BCR), consisting of the mu heavy chain (mHC) and the surrogate light chain (SLC, Vpre-B and lambda-5), plays important roles during B cell development.
More...The pre-B cell receptor (pre-BCR), consisting of the mu heavy chain (mHC) and the surrogate light chain (SLC, Vpre-B and lambda-5), plays important roles during B cell development. The formation of the pre-BCR, which enables the nascent immunoglobulin HC to associate with the SLC, is considered a prerequisite for B cell development. However, a significant number of peripheral mature (leaky) B cells exist in SLC-deficient mice. These leaky B cells develop in the absence of pre-BCR and do not undergo the pre-BCR checkpoint. The antibody repertoires of leaky B cells thus reflect the absence of pre-BCR function. To investigate how the absence of the pre-BCR is circumvented by these leaky-B cells and examine the effect of the pre-BCR checkpoint on the antibody system, we analyzed the antibody repertoires of lambda-5_deficient mice using next-generation sequencing.
Less...| Accession | PRJDB7998 |
| Data Type | Targeted Locus (Loci) |
| Scope | Multiisolate |
| Organism | Mus musculus[Taxonomy ID: 10090] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus |
| Publications | Sun L et al., "Distorted antibody repertoire developed in the absence of pre-B cell receptor formation.", Biochem Biophys Res Commun, 2018 Jan 1;495(1):1411-1417 |
| Grants | - "Grant-in-Aid for Challenging Exploratory Research" (Grant ID 15K15159, Ministry of Education, Culture, Sports, Science, and Technology)
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| Submission | Registration date: 7-Feb-2019
Immunology, National Institute of Infectious Diseases |
| Relevance | Medical |
Project Data:
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| Publications |
| PubMed | 1 |
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