The iPSCORE Resource of human induced pluripotent stem cells (hiPSCs) was created as part of the Next-Gen Consortium funded by the NHLBI. The overarching purpose of the iPSCORE Resource is to provide a large collection of hiPSCs and their derived cell types for use in studying the impact of genetic variation on proximate molecular phenotypes. This Resource is being used in a number of ongoing studies for which genomic data will be generated and deposited into public repositories and linked through this bioProject umbrella. A total of 273 individuals have participated in the study for which 222 have had hiPSCs generated from fibroblasts (available through WiCell (http://www.wicell.org/)). Of the 273 individuals, 181 are part of 55 families that include 24 monozygotic twin pairs and 5 dizygotic twin pairs, allowing for the incorporation of familial relationships into genetic analyses.
More...The iPSCORE Resource of human induced pluripotent stem cells (hiPSCs) was created as part of the Next-Gen Consortium funded by the NHLBI. The overarching purpose of the iPSCORE Resource is to provide a large collection of hiPSCs and their derived cell types for use in studying the impact of genetic variation on proximate molecular phenotypes. This Resource is being used in a number of ongoing studies for which genomic data will be generated and deposited into public repositories and linked through this bioProject umbrella. A total of 273 individuals have participated in the study for which 222 have had hiPSCs generated from fibroblasts (available through WiCell (http://www.wicell.org/)). Of the 273 individuals, 181 are part of 55 families that include 24 monozygotic twin pairs and 5 dizygotic twin pairs, allowing for the incorporation of familial relationships into genetic analyses. Germline DNA has been sequenced from blood or fibroblast samples for all 273 individuals. Extensive molecular data is available for the hiPSCs as well as derived cell types.
Less...| Accession | PRJNA521229 |
| Type | Umbrella project |
| Submission | Registration date: 6-Feb-2019
THE REGENTS OF THE UNIV. OF CALIF., UNIV. OF CALIF., SAN DIEGO |
| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
|---|
| Sequence data |
| SRA Experiments | 922 |
| Publications |
| PubMed | 2 |
| PMC | 2 |
| Other datasets |
| BioSample | 1097 |
| Genotype and Phenotype (dbGaP) | 1 |
| GEO DataSets | 3 |
This project encompasses the following 5 sub-projects:
| Project Type | Number of Projects |
| Other | 2 |
BioProject
accession | Organism | Title |
|---|
| PRJNA516703 | Homo sapiens | Subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression (University of California,...) | | PRJNA554117 | Homo sapiens | Allele-specific NKX2-5 binding underlies multiple genetic associations with human electrocardiographic traits (Kelly Frazer, Pediatrics,...) |
|
| Phenotype or Genotype | 1 |
BioProject
accession | Organism | Title |
|---|
| PRJNA285375 | Homo sapiens | NextGen Consortium: The iPSCORE (iPSC Collection for Omic Research) Resource (THE REGENTS OF THE UNIV....) |
|
| Umbrella project | 1 |
BioProject
accession | Organism | Title |
|---|
| PRJNA285374 | Homo sapiens | NextGen Consortium: The iPSCORE (iPSC Collection for Omic Research) Resource (NHLBI) |
|
| variation | 1 |
BioProject
accession | Organism | Title |
|---|
| PRJNA549750 | Homo sapiens | Allele-Specific NKX2-5 Binding Underlies Multiple Genetic Associations with Human Electrocardiographic Traits (NextGen Consortium) |
|