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Accession: PRJNA521226 ID: 521226

Precise Gene Editing Preserves Hematopoietic Stem Cell Function Following Transient p53-Mediate DNA Damage Response [Clear-seq] (human)

See Genome Information for Homo sapiens
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This project is a component of the Precise Gene Editing Preserves Hematopoietic Stem Cell Function Following Transient p53-Mediate DNA Damage Response
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3 additional projects are components of the Precise Gene Editing Preserves Hematopoietic Stem Cell Function Following Transient p53-Mediate DNA Damage Response.
66644 additional projects are related by organism.
We analysed AAVS1 edited cells in presence and absence of GSE56 (p53 inhibitor) 14 days upon electroporation to evaluate whether p53 transient inhibition by GSE56 could aggravate the genotoxicity risk of the procedure Overall design: We deep sequenced a panel of 151 cancer-associated genes, including TP53, in cultured HSPC edited with AAVS1 HS RNP in the presence or not of GSE56 from three independent donors. More...
AccessionPRJNA521226; GEO: GSE126163
ScopeMultiisolate
OrganismHomo sapiens[Taxonomy ID: 9606]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens
PublicationsSchiroli G et al., "Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response.", Cell Stem Cell, 2019 Apr 4;24(4):551-565.e8
SubmissionRegistration date: 6-Feb-2019
Bioinformatics, CNR-ITB
RelevanceMedical
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments9
Publications
PubMed1
PMC1
Other datasets
BioSample9
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes1
SRA Data Details
ParameterValue
Data volume, Gbases31
Data volume, Mbytes14023

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