This SuperSeries is composed of the SubSeries listed below.
Overall design: Refer to individual Series
| Accession | PRJNA521140; GEO: GSE126147 |
| Type | Umbrella project |
| Publications | Liu Z et al., "CASZ1 induces skeletal muscle and rhabdomyosarcoma differentiation through a feed-forward loop with MYOD and MYOG.", Nat Commun, 2020 Feb 14;11(1):911 |
| Submission | Registration date: 6-Feb-2019
POB, NCI |
| Relevance | Superseries |
Project Data:
| Resource Name | Number
of Links |
|---|
| Sequence data |
| SRA Experiments | 57 |
| Publications |
| PubMed | 1 |
| PMC | 1 |
| Other datasets |
| BioSample | 57 |
| GEO DataSets | 8 |
CASZ1 directly regulates expression of myogenic genes through regional epigenetic modifications to induce muscle and rhabdomyosarcoma cell differentiation encompasses the following 7 sub-projects:
| Project Type | Number of Projects |
| Epigenomics | 4 |
BioProject
accession | Organism | Title |
|---|
| PRJNA521144 | Homo sapiens | Investigate the affect of CASZ1b on chromatin accessibility in SMS-CTR cells (POB, NCI) | | PRJNA521147 | Homo sapiens | Genome-wide mapping of CASZ1 binding sites in differentiated SMS-CTR cells [Trametinib] (POB, NCI) | | PRJNA521148 | Homo sapiens | Genome-wide mapping of CASZ1b binding sites and investigate its effect on chromatin status in SMS-CTR cells [CTRtetCASZ1b] (POB, NCI) | | PRJNA521145 | Mus musculus | The affect of loss of Casz1 in C2C12 cells on super-enhancers (POB, NCI) |
|
| Transcriptome or Gene expression | 3 |
BioProject
accession | Organism | Title |
|---|
| PRJNA521141 | Homo sapiens | RNA-sequencing analysis to investigate genes regulated by CASZ1 in RD cells (POB, NCI) | | PRJNA521143 | Homo sapiens | RNA-sequencing analysis to investigate genes regulated by CASZ1 in SMS-CTR cells (POB, NCI) | | PRJNA521142 | Mus musculus | RNA-sequencing analysis to investigate genes regulated by CASZ1 in C2C12 cells (POB, NCI) |
|