BioProject

Brain and spinal injury often impair sensorimotor processing in the spinal cord and reduce mobility. More...

Brain and spinal injury often impair sensorimotor processing in the spinal cord and reduce mobility. Cortical stroke in rats leads to long-term deficits in dexterity and walking. Subcutaneous neurotrophin-3 infusion initiated at a clinically-feasible time-point after injury improved walking and dexterity. We discovered that Neurotrophin-3 is transported in sensory afferents from muscles to the dorsal root ganglia. Using genome-wide RNA sequencing of the whole cervical level 6-8 dorsal root ganglia, we sought gene changes in afferent neurons that were present at two timepoints after stroke. Overall design: RNA-Seq was performed on whole C6-8 dorsal root ganglia of rats from three different groups: naïve rats, rats after unilateral cortical stroke+vehicle infusion and rats after unilateral cortical stroke and NT3 infusion. Differential expression was analyzed between each of the groups. Less...