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Genome Information for Homo sapiens
Differential gene expression analysis of RNA extracted from omental tumors from Foxn1nu NU/J athymic female mice injected with cells from the human ovarian tumor cell line SKOV3ip-GFP followed by oral treatment with either R-ketorolac or a placebo.
More...Differential gene expression analysis of RNA extracted from omental tumors from Foxn1nu NU/J athymic female mice injected with cells from the human ovarian tumor cell line SKOV3ip-GFP followed by oral treatment with either R-ketorolac or a placebo. R-ketorolac is an inhibitor of Rac1 and Cdc42 GTPases. Mice were provided placebo or 1 mg/kg/d of R-ketorolac to approximate human dose of racemic drug. Drug treatment continued for 14 days before sacrifice and collection of tumor tissue. Extracted RNA was sequenced on the Ion Proton S5/XL platform.
Less...| Accession | PRJNA518157 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens |
| Grants | - "Ketorolac and Related NSAIDs for Targeting Rho-family GTPases in Ovarian Cancer" (Grant ID R21 TR001731, National Center for Advancing Translational Sciences)
- "Keck-UNM Genomics Shared Resource" (Grant ID P30 CA118100, National Cancer Institute)
- "Capitalizing on NSAID enantiomer selectivity for cancer prevention and therapy(PQ" (Grant ID R21 CA170375, National Cancer Institute)
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| Submission | Registration date: 31-Jan-2019
University of New Mexico Comprehensive Cancer Center |
| Relevance | Medical |
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