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Genome Information for Mus musculus
To gain insight into layers of gene expression in response to oxidative stress, we obtained transcriptomic profiles by RNA sequencing.
More...To gain insight into layers of gene expression in response to oxidative stress, we obtained transcriptomic profiles by RNA sequencing. Immortalized mouse embryonic fibroblasts (MEFs) were used that carried either wildtype eIF2α (WT) or a point mutant in which the inhibitory Ser 51 phosphorylation site was replaced by alanine (eIF2αS51A) thus rendering eIF2α insensitive to kinase-mediated inhibition and translational shutdown in response to stress (Randy Kaufman paper, McEwen 2005). To monitor acute and prolonged responses to oxidative stress, cells were exposed for either 15 or 120 minutes to 500 mM H2O2, and triplicate RNA samples were obtained for sequencing.
Less...| Accession | PRJNA517725 |
| Data Type | Genome sequencing and assembly, Raw sequence reads, Genome sequencing, Assembly, Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Mus musculus[Taxonomy ID: 10090] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus |
| Submission | Registration date: 29-Jan-2019
Sanford Burnham Prebys Medical Discovery Institute |
Project Data:
| Resource Name | Number
of Links |
|---|
| BioSample | 18 |
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