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Accession: PRJNA517508 ID: 517508

Transcription profiling of IL-4-expressing CD4 T cells in the lung and lung-draining lymph nodes (house mouse)

See Genome Information for Mus musculus
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47588 additional projects are related by organism.
Using single cell RNA-sequencing and whole-genome targeted transcription profiling, this study reveals that helminth infection causes the expansion of distinct but clonally related IL-4-competent CD4+ T cells in the lung and lung-draining lymphoid tissues providing insight into tissue-specific mechanisms of type-2 cytokine regulation and the lineage commitment of T-helper 2 (Th2) and T follicular helper (Tfh) cells. More...
AccessionPRJNA517508; GEO: GSE125788
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismMus musculus[Taxonomy ID: 10090]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus
PublicationsBrown IK et al., "Single cell analysis of host response to helminth infection reveals the clonal breadth, heterogeneity, and tissue-specific programming of the responding CD4+ T cell repertoire.", PLoS Pathog, 2021 Jun;17(6):e1009602
Grants
  • "The Role of BATF in Allergic Inflammation and Anti-Helminth Immunity" (Grant ID R01 AI119004, National Institute of Allergy and Infectious Diseases Extramural Activities)
  • "The Origin and Role of Pulmonary ILC2 Subsets in Anti-Helminth Immunity" (Grant ID R01 AI156901, National Institute of Allergy and Infectious Diseases Extramural Activities)
SubmissionRegistration date: 28-Jan-2019
Reinhardt, Biomedical Research, National Jewish Health
RelevanceModel Organism
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments29
Publications
PubMed1
PMC1
Other datasets
BioSample29
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes298
SRA Data Details
ParameterValue
Data volume, Gbases94
Data volume, Mbytes43572

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