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Accession: PRJNA517274 ID: 517274

Inducible histone K-to-M mutations are dynamic tools to probe the physiological role of site-specific histone methylation in vitro and in vivo (house mouse)

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Here, we developed mouse models expressing inducible lysine to methionine mutants of histone H3, which function as dominant negative inhibitors of methylation at their respective sites. More...
AccessionPRJNA517274; GEO: GSE125703
Data TypeEpigenomics
ScopeMultiisolate
OrganismMus musculus[Taxonomy ID: 10090]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus
PublicationsBrumbaugh J et al., "Inducible histone K-to-M mutations are dynamic tools to probe the physiological role of site-specific histone methylation in vitro and in vivo.", Nat Cell Biol, 2019 Nov;21(11):1449-1461
SubmissionRegistration date: 26-Jan-2019
Bernstein's lab, Pathology, Massachusetts General Hospital
RelevanceModel Organism
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments18
Publications
PubMed1
PMC1
Other datasets
BioSample18
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes387
SRA Data Details
ParameterValue
Data volume, Gbases49
Data volume, Mbytes21135

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