BioProject

In vitro studies of subcutaneous (SC) abdominal adipose stem cells (ASC) from women with polycystic ovary syndrome (PCOS) show altered ASC commitment to preadipocytes and differentiation to mature adipocytes related to hyperandrogenism. More...

In vitro studies of subcutaneous (SC) abdominal adipose stem cells (ASC) from women with polycystic ovary syndrome (PCOS) show altered ASC commitment to preadipocytes and differentiation to mature adipocytes related to hyperandrogenism. The goal of the study is to use microarrays to examine whether SC abdominal ASC gene expression are altered in normal-weight PCOS women and correlated with hyperandrogenemia and/or insulin resistance, which are prevalent clinical pathologies of PCOS. Overall design: ASCs were isolated from SC adipose tissue following SC abdominal biopsy in 4 PCOS women and 4 age and BMI matched controls for gene expression comparison. First generation of stem cells were cultured until cells reached confluency and isolated for RNA extraction and hybridization on Affymetrix microarrays. Grant#: P50 HD071836 Title: Androgen excess as a mechanism for adipogenic dysfunction in PCOS women Period: 2018-2022 Less...