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Genome Information for Homo sapiens
We compare differences in gene expression induced after 6 hours of exposure to one of three CDK4/6 inhibitors or a pan-CDK inhibitor
Overall design: mRNA levels for 7 breast cancer cell lines or PDX models treated with one of three CDK4/6 inhibitors (abemaciclib, palbociclib, or ribociclib) at 4 concentrations (0.1, 0.3, 1, 3 um) or the pan-CDK inhibitor alvocidib at 2 concentrations (0.1, 1 um) in triplicate.
| Accession | PRJNA515531; GEO: GSE125215 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens |
| Publications | Hafner M et al., "Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity.", Cell Chem Biol, 2019 Aug 15;26(8):1067-1080.e8 |
| Submission | Registration date: 16-Jan-2019
Harvard Medical School |
| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
|---|
| Sequence data |
| SRA Experiments | 335 |
| Publications |
| PubMed | 1 |
| PMC | 1 |
| Other datasets |
| BioSample | 335 |
| GEO DataSets | 1 |