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Accession: PRJNA515333 ID: 515333

Genome-wide analysis of gene expression from islets of different sizes in response to in vivo serpin B13 mAB treatment (house mouse)

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47588 additional projects are related by organism.
By using oligonucleotide microarray-based technology as a tool for rapid mapping of unique differences in gene expression, we found that inhibiting serpin B13 in BALB/c mice treated with a mAb according to our protocol resulted in the upregulation of relatively few genes, including several Reg genes, which have been implicated in β-cell proliferation. More...
AccessionPRJNA515333; GEO: GSE125151
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismMus musculus[Taxonomy ID: 10090]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus
PublicationsLo CW et al., "Cellular proliferation in mouse and human pancreatic islets is regulated by serpin B13 inhibition and downstream targeting of E-cadherin by cathepsin L.", Diabetologia, 2019 May;62(5):822-834
SubmissionRegistration date: 15-Jan-2019
Biology, U of Rochester
RelevanceModel Organism
Project Data:
Resource NameNumber
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Publications
PubMed1
Other datasets
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Spots271686
Data volume, Processed Mbytes9
Data volume, Supplementary Mbytes12

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