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Accession: PRJNA514365 ID: 514365

Hypersensitive interferon responses in lupus keratinocytes reveal key mechanistic determinants in cutaneous lupus (human)

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66644 additional projects are related by organism.
SLE patients exhibit increased interferon signatures in their skin secondary to increased production and a robust, skewed IFN response that is regulated by PITX1. More...
AccessionPRJNA514365; GEO: GSE124939
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismHomo sapiens[Taxonomy ID: 9606]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens
PublicationsTsoi LC et al., "Hypersensitive IFN Responses in Lupus Keratinocytes Reveal Key Mechanistic Determinants in Cutaneous Lupus.", J Immunol, 2019 Apr 1;202(7):2121-2130
Grants
  • "Integrative Biology Approach to Identify and Characterize Roles of lncRNAs Associated with Psoriasis Pathology" (Grant ID K01 AR072129, National Institute of Arthritis and Musculoskeletal and Skin Diseases)
  • "The Role of Innate Immunity in Systemic and Cutaneous Lupus" (Grant ID K08 AR063668, National Institute of Arthritis and Musculoskeletal and Skin Diseases)
  • "Characterization of Interferon Kappa as a Novel Target in Cutaneous Lupus" (Grant ID R01 AR071384, National Institute of Arthritis and Musculoskeletal and Skin Diseases)
  • "Understanding Transcriptional Connections between Cutaneous and Systemic Lupus" (Grant ID R03 AR066337, National Institute of Arthritis and Musculoskeletal and Skin Diseases)
SubmissionRegistration date: 10-Jan-2019
University of Michigan
RelevanceMedical
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments72
Publications
PubMed1
PMC1
Other datasets
BioSample72
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes3
SRA Data Details
ParameterValue
Data volume, Gbases217
Data volume, Mbytes87380

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