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Accession: PRJNA514102 ID: 514102

The transcription factor ERG regulates super-enhancers in endothelial cells [ERG siRNA] (human)

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This project is a component of the The transcription factor ERG regulates super-enhancers in endothelial cells
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1 additional project is a component of the The transcription factor ERG regulates super-enhancers in endothelial cells.
66644 additional projects are related by organism.
We provide the functional and epigenomic evidence for ERG binding to super-enhancers in HUVEC and further show that loss of ERG results in inhibition of specific endothelial super-enhancers and associated target genes. More...
AccessionPRJNA514102; GEO: GSE124892
Data TypeEpigenomics
ScopeMultiisolate
OrganismHomo sapiens[Taxonomy ID: 9606]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens
Publications
  • Peghaire C et al., "The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature.", Nat Commun, 2019 Nov 1;10(1):5014
  • Kalna V et al., "The Transcription Factor ERG Regulates Super-Enhancers Associated With an Endothelial-Specific Gene Expression Program.", Circ Res, 2019 Apr 26;124(9):1337-1349
SubmissionRegistration date: 9-Jan-2019
National Heart and Lung Institute, Imperial College London
RelevanceMedical
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments5
Publications
PubMed2
PMC2
Other datasets
BioSample5
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes683
SRA Data Details
ParameterValue
Data volume, Gbases13
Data volume, Mbytes4922

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