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Accession: PRJNA514055 ID: 514055

Pan-HDAC Inhibition Reverses the Warburg Effect and Leads to Metabolic Vulnerabilities (human)

See Genome Information for Homo sapiens
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66644 additional projects are related by organism.
We report the HDAC inhibiton of glioblastoma cells causes histone H3K27 acetylation and leads to upreguated OXPHOS master regulator PGC1a which then leads to an increase in mitochondrial fusion, mitochondrial biogenesis and higher mitochondrial oxygen consumption rate coupled with increased fatty acid oxidation (FAO). More...
AccessionPRJNA514055; GEO: GSE124877
Data TypeEpigenomics
ScopeMultiisolate
OrganismHomo sapiens[Taxonomy ID: 9606]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens
Grants
  • "Dual Inhibition of Mitochondrial Matrix Chaperones and Anti-Apoptotic Bcl-2 Family Members for Glioblastoma Therapy." (Grant ID R01 NS095848, National Institute of Neurological Disorders and Stroke)
  • "Targeting Mutant IDH1 for a Novel Synthetic Lethal Interaction in Malignant Gliomas" (Grant ID R01 NS102366, National Institute of Neurological Disorders and Stroke)
SubmissionRegistration date: 9-Jan-2019
Columbia University Medical Center
RelevanceMedical
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments20
Other datasets
BioSample20
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes8
SRA Data Details
ParameterValue
Data volume, Gbases26
Data volume, Mbytes9233

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