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Genome Information for Mus musculus
High-throughput RNA-seq approach was used to profile transcriptional ISC niche responses in SAMP mice versus healthy controls (AKR)
Overall design: The RNA-seq transcriptional analysis was performed on ISC niche laser captured from small intestine using three independent samples (biological replicates) of each mouse group with defined total inflammatory score: ileal ISC niches from inflammation-free SAMP-5 (5-wk old) and AKR-25 (25-wk old) mice, and from highly diseased SAMP-25 mice (25-wk old) with Crohn's disease-like ileitis.
| Accession | PRJNA513868; GEO: GSE124825 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Mus musculus[Taxonomy ID: 10090] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus |
| Publications | Buttó LF et al., "Intestinal Stem Cell Niche Defects Result in Impaired 3D Organoid Formation in Mouse Models of Crohn's Disease-like Ileitis.", Stem Cell Reports, 2020 Aug 11;15(2):389-407 |
| Submission | Registration date: 8-Jan-2019
CWRU |
| Relevance | Model Organism |
Project Data:
| Resource Name | Number
of Links |
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| Sequence data |
| SRA Experiments | 9 |
| Publications |
| PubMed | 1 |
| PMC | 1 |
| Other datasets |
| BioSample | 9 |
| GEO DataSets | 1 |