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2 additional projects are components of the VD3-VDR axis regulates the homeostasis and function of alveolar macrophage.
Purpose: To understand the regulation of gene expression of alveolar macrophages by VD3-VDR axis
Overall design: Fresh isolated WT alveolar macropahges (AM) were treated with LPS (100ng/mL) or LPS plus 50 nM Vitamin D3 in vitro for 4hrs. RNA was isolated and purified by Qiagen Rneasy micro kit and applied to RNAseq.
| Accession | PRJNA513265; GEO: GSE124723 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Mus musculus[Taxonomy ID: 10090] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus |
| Publications | Hu G et al., "Vitamin D3-vitamin D receptor axis suppresses pulmonary emphysema by maintaining alveolar macrophage homeostasis and function.", EBioMedicine, 2019 Jul;45:563-577 |
| Submission | Registration date: 7-Jan-2019
Chen, Koch Institute, MIT |
| Relevance | Model Organism |
Project Data:
| Resource Name | Number
of Links |
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| Sequence data |
| SRA Experiments | 6 |
| Publications |
| PubMed | 1 |
| PMC | 1 |
| Other datasets |
| BioSample | 6 |
| GEO DataSets | 1 |