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Accession: PRJNA477818 ID: 477818

Small RNA-seq analysis shows reduced tRNA levels in cdk1-as1 mutants (baker's yeast)

See Genome Information for Saccharomyces cerevisiae
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4197 additional projects are related by organism.
Purpose: Determine whether Cdk1 only regulates a specific subset of tDNAs, or whether Cdk1 has a more global impact on tDNA expression; Method: We study the expression of tRNA genes in WT cells and cdk1-as1 mutants during S phase by small-RNAseq; Result: We found that expression of at least 77% of all tDNAs is significantly downregulated in S-phase in the cdk1-as1 mutant compared with the WT strain; Conclussions: Cdk1 promotes transcription of the majority of tRNA genes during the cell cycle. More...
AccessionPRJNA477818; GEO: GSE116224
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismSaccharomyces cerevisiae[Taxonomy ID: 4932]
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae
PublicationsHerrera MC et al., "Cdk1 gates cell cycle-dependent tRNA synthesis by regulating RNA polymerase III activity.", Nucleic Acids Res, 2018 Dec 14;46(22):11698-11711
SubmissionRegistration date: 25-Jun-2018
Enserink Jorrit, Molecular Cell Biology, Oslo University Hospital
RelevanceModel Organism
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Sequence data
SRA Experiments2
Publications
PubMed1
PMC1
Other datasets
BioSample2
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes1
SRA Data Details
ParameterValue
Data volume, Gbases5
Data volume, Mbytes1837

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