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Accession: PRJNA476714 ID: 476714

SUMO-targeted ubiquitin ligases (STUbLs) reduce the toxicity and abnormal transcriptional activity associated with a mutant, aggregation-prone fragment of huntingtin (baker's yeast)

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We report that the SUMO-targeted ubiquitin ligase (STUbL) Slx5 reduces the toxicity and abnormal transcriptional activity of a mutant, aggregation-prone fragment of huntingtin (htt), the causative agent of HD. More...
AccessionPRJNA476714; GEO: GSE115990
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismSaccharomyces cerevisiae[Taxonomy ID: 4932]
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae
PublicationsOhkuni K et al., "SUMO-Targeted Ubiquitin Ligases (STUbLs) Reduce the Toxicity and Abnormal Transcriptional Activity Associated With a Mutant, Aggregation-Prone Fragment of Huntingtin.", Front Genet, 2018;9:379
SubmissionRegistration date: 19-Jun-2018
Biomedical Informatics and Data Science (BIDS) Directorate, Frederick National Labroatory for Cancer Research
RelevanceModel Organism
Project Data:
Resource NameNumber
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Sequence data
SRA Experiments11
Publications
PubMed1
PMC1
Other datasets
BioSample11
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes2
SRA Data Details
ParameterValue
Data volume, Gbases110
Data volume, Mbytes40411

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