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Accession: PRJNA476701 ID: 476701

Mutant p53 regulates enhancer-associated H3K4 monomethylation through interactions with the methyltransferase MLL4 (human)

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In this study, we establish a mechanism in which mutant p53 cooperates with MLL4 to regulate aberrant enhancer activity and tumor promoting gene expression in response to chronic TNF-a signaling. More...
AccessionPRJNA476701; GEO: GSE115985
Data TypeEpigenomics
ScopeMultiisolate
OrganismHomo sapiens[Taxonomy ID: 9606]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens
PublicationsRahnamoun H et al., "Mutant p53 regulates enhancer-associated H3K4 monomethylation through interactions with the methyltransferase MLL4.", J Biol Chem, 2018 Aug 24;293(34):13234-13246
SubmissionRegistration date: 19-Jun-2018
Lauberth Lab, Biological Sciences, UCSD
RelevanceMedical
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments5
Publications
PubMed1
PMC1
Other datasets
BioSample5
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes1249
SRA Data Details
ParameterValue
Data volume, Gbases20
Data volume, Mbytes7710

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