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Accession: PRJNA476558 ID: 476558

p53 binding and chromatin dynamics after etoposide treatment of primary lung fibroblast (human)

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66643 additional projects are related by organism.
We report the chromatin modification dynamics at p53 binding sites afte 6 hours of treatment of etoposide (100 micromolar final) in IMR90 human lung fibroblasts using ChIP-seq , ATAC-seq, and polyA+ RNA-seq analyses. More...
AccessionPRJNA476558; GEO: GSE115940
ScopeMultiisolate
OrganismHomo sapiens[Taxonomy ID: 9606]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens
PublicationsCatizone AN et al., "Comparison of genotoxic versus nongenotoxic stabilization of p53 provides insight into parallel stress-responsive transcriptional networks.", Cell Cycle, 2019 Apr;18(8):809-823
Grants
  • "Molecular mechanisms regulating the establishment of cis-regulatory elements by the transcription factor p63" (Grant ID R15 GM128049, National Institute of General Medical Sciences)
SubmissionRegistration date: 18-Jun-2018
Sammons, Biological Sciences, University at Albany - SUNY
RelevanceMedical
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments11
Publications
PubMed1
PMC1
Other datasets
BioSample11
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes465
SRA Data Details
ParameterValue
Data volume, Gbases63
Data volume, Mbytes36728

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