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1 additional project is a component of the H3.3 K27M depletion increases differentiation and extends latency of diffuse intrinsic pontine glioma growth in vivo.
xenografts from human pediatric brainstem gliomas bearing K27M in H3F3A were transduced with non silencing or H3F3A shRNA to assess the impact of the K27M on tumor growth, gene expression and epigenetics
Overall design: RNA-seq and ChIP-seq for H3K27me3 and H3K4me3 for knock-down or control tumors from three different human xenografts. Multiple tumors tested for each xenograft line.
| Accession | PRJNA476347; GEO: GSE115873 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens |
| Publications | - Silveira AB et al., "Correction to: H3.3 K27M depletion increases differentiation and extends latency of diffuse intrinsic pontine glioma growth in vivo.", Acta Neuropathol, 2019 Jun;137(6):1021
- Silveira AB et al., "H3.3 K27M depletion increases differentiation and extends latency of diffuse intrinsic pontine glioma growth in vivo.", Acta Neuropathol, 2019 Apr;137(4):637-655
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| Submission | Registration date: 15-Jun-2018
Developmental Neurology, St Jude Children's Research Hospital |
| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
|---|
| Sequence data |
| SRA Experiments | 50 |
| Publications |
| PubMed | 2 |
| PMC | 2 |
| Other datasets |
| BioSample | 50 |
| GEO DataSets | 1 |