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Accession: PRJNA475791 ID: 475791

RNAseq of motor neurons and neurons with differential vulnerability isolated from a mouse model of spinal muscular atrophy using laser capture microdissection (house mouse)

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47588 additional projects are related by organism.
Motor neurons are selectively vulnerable in spinal muscular atrophy (SMA). However, some brainstem motor neuron groups, including oculomotor and trochlear, which innervate the muscles around the eyes, are for unknown reasons spared. More...
AccessionPRJNA475791; GEO: GSE115706
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismMus musculus[Taxonomy ID: 10090]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus
PublicationsNichterwitz S et al., "LCM-seq reveals unique transcriptional adaptation mechanisms of resistant neurons and identifies protective pathways in spinal muscular atrophy.", Genome Res, 2020 Aug;30(8):1083-1096
SubmissionRegistration date: 12-Jun-2018
Hedlund, Biomedicum D7, Department of Neuroscience, Karolinska Institutet
RelevanceModel Organism
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments168
Publications
PubMed1
PMC1
Other datasets
BioSample168
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes19
SRA Data Details
ParameterValue
Data volume, Gbases102
Data volume, Mbytes98004

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