BioProject

The goal of this experiment was to use global gene expression profiling to assess the global genetic reprogramming of different types of splenic mononuclear phagocytes early after MCMV infection in vivo. More...

The goal of this experiment was to use global gene expression profiling to assess the global genetic reprogramming of different types of splenic mononuclear phagocytes early after MCMV infection in vivo. This study includes new samples (GSM3178486-GSM3178497; available below) profiling splenic CD11b+ conventional dendritic cells (cDC2), classical monocytes (cMo) and red pulp macrophages (RPM) from untreated or day 1.5 MCMV-infected mice together with re-analysis of previously published data in order to examine the similarities in the pDC gene expression profiles across datasets. The complete processed data for all analyzed samples, with and without batch correction, are available at the foot of this series. Included is a text file with a list of all re-analyzed samples and data processing protocols for the re-analysis. Overall design: The new samples in this series are for a comparison of the gene expression programs of different types of resting or MCMV-activated mononuclear phagocytes isolated from the spleen of untreated versus d1.5 infected wild-type CD45.2 C57BL/6 mice. Less...