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Accession: PRJNA474837 ID: 474837

Inflammation-produced TNFα protects hematopoietic stem cells from necroptosis and promotes hematopoietic regeneration (house mouse)

See Genome Information for Mus musculus
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47588 additional projects are related by organism.
To gain molecular insights into the differential effect of TNFα between hematopoietic stem cells (HSC) and downstream myeloid progenitors, we performed RNA-sequencing analyses of HSCs and granulocyte-macrophage progenitors (GMP) treated with TNFα both ex vivo and in vivo. More...
AccessionPRJNA474837; GEO: GSE115403
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismMus musculus[Taxonomy ID: 10090]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus
PublicationsYamashita M et al., "TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration.", Cell Stem Cell, 2019 Sep 5;25(3):357-372.e7
SubmissionRegistration date: 6-Jun-2018
Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo
RelevanceModel Organism
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments36
Publications
PubMed1
PMC1
Other datasets
BioSample36
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes12
SRA Data Details
ParameterValue
Data volume, Gbases37
Data volume, Mbytes14048

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