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Accession: PRJNA474240 ID: 474240

Expanding Hematopoietic Stem Cell pool through Fine tuning of Tpo receptor with diabodies. (human)

See Genome Information for Homo sapiens
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66643 additional projects are related by organism.
Class I cytokine receptors such as Thrombopoietin receptor (MPL) are dimers, but it is unclear whether remodeling receptor dimer topology is a viable strategy to "tune" signaling output. More...
AccessionPRJNA474240; GEO: GSE115235
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismHomo sapiens[Taxonomy ID: 9606]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens
PublicationsCui L et al., "Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors.", Proc Natl Acad Sci U S A, 2021 Jan 12;118(2)
SubmissionRegistration date: 1-Jun-2018
Gerlinde Wernig Lab, Pathology, Institute for Regenerative Medicine and Stem Cell Research, Stanford University School of Medicine
RelevanceMedical
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments659
Publications
PubMed1
PMC1
Other datasets
BioSample659
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes6
SRA Data Details
ParameterValue
Data volume, Gbases158
Data volume, Mbytes64173

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