See
Genome Information for Homo sapiens
We generated a collection of patient-derived pancreatic normal and cancer organoids. We performed whole genome sequencing, targeted exome sequencing, and RNA sequencing on organoids as well as matched tumor and normal tissue if available. This dataset is a valuable resource for pancreas cancer researchers, and those looking to compare primary tissue to organoid culture. In our linked publication, we show that pancreatic cancer organoids recapitulate the mutational spectrum of pancreatic cancer. Furthermore, RNA sequencing of organoids demonstrates the presence of both transcriptional subtypes of pancreas cancer.
| Accession | PRJNA473873; dbGaP: phs001611 |
| Type | Umbrella project (Subtype:Authorized Access) |
| Organism | Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens |
| Submission | Registration date: 31-May-2018
NCI |
| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
|---|
| BioSample | 188 |
| Genotype and Phenotype (dbGaP) | 1 |
Organoid profiling identifies common responders to chemotherapy in pancreatic cancer encompasses the following sub-project:
| Project Type | Number of Projects |
| Phenotype or Genotype | 1 |
BioProject
accession | Organism | Title |
|---|
| PRJNA473874 | Homo sapiens | Organoid profiling identifies common responders to chemotherapy in pancreatic cancer (COLD SPRING HARBOR LABORATORY) |
|