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Accession: PRJNA473839 ID: 473839

ADAR1-editing in HeLa, p150-KO and ADAR1-KO transcriptomes (human)

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This project is a component of the ADAR1-editing of cellular and measles virus-derived duplex RNA
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1 additional project is a component of the ADAR1-editing of cellular and measles virus-derived duplex RNA.
66643 additional projects are related by organism.
RNAseq analysis of cell lines with ADAR1-p150 and ADAR1-p110 knock-outs and primary human tissue samples (from GSE57353 and GSE99392 data sets) to identify sites of ADAR1 editing Overall design: 12 samples: 3 cell lines (HeLa, HeLa-p150KO, HeLa-ADAR1KO) with four conditions each (no treatment, MeV-vac2(GFP)-infected, MeV-CKO(GFP)-infected, IFNA/D-treated). More...
AccessionPRJNA473839; GEO: GSE115127
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismHomo sapiens[Taxonomy ID: 9606]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens
PublicationsPfaller CK et al., "Extensive editing of cellular and viral double-stranded RNA structures accounts for innate immunity suppression and the proviral activity of ADAR1p150.", PLoS Biol, 2018 Nov;16(11):e2006577
Grants
  • "Measles virus C protein: polymerase interactions and innate immunity evasion" (Grant ID R21 AI128037, National Institute of Allergy and Infectious Diseases Extramural Activities)
SubmissionRegistration date: 30-May-2018
Molecular Medicine, Mayo Clinic
RelevanceMedical
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments12
Publications
PubMed1
PMC1
Other datasets
BioSample12
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes17
SRA Data Details
ParameterValue
Data volume, Gbases164
Data volume, Mbytes57568

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