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Genome Information for Caenorhabditis elegans
Stress resistance induced by mild environmental stress protects animals against aging-associated cellular damages and promotes longevity. Here, we reveal that mild heat triggers innate immune and detoxification responses that confers longevity at warm temperatures. We compared the transcriptome of 25°C-cultivated animals to that of 15°C controls through RNA-seq analysis. A total of 1958 transcripts were differentially regulated, with 1143 up-regulations and 815 down-regulations.
Overall design: RNA from 15°C and 25°C-cultivated wild type C. elegans developed to the L4 stage was extracted and analyzed by RNA sequencing. Genes having a fold change of > 2 (either up or down) and FDR of < 0.01 were considered as high temperature-regulated genes.
| Accession | PRJNA473811; GEO: GSE115095 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Caenorhabditis elegans[Taxonomy ID: 6239] Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis; Caenorhabditis elegans |
| Publications | Zhou L et al., "Histone acetylation promotes long-lasting defense responses and longevity following early life heat stress.", PLoS Genet, 2019 Apr;15(4):e1008122 |
| Submission | Registration date: 30-May-2018
Chongqing University |
| Relevance | Model Organism |
Project Data:
| Resource Name | Number
of Links |
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| Sequence data |
| SRA Experiments | 6 |
| Publications |
| PubMed | 1 |
| PMC | 1 |
| Other datasets |
| BioSample | 6 |
| GEO DataSets | 1 |