This works reveals that denervation induces the accumulation of FAPs with an aberrant activation of the IL6-STAT3 signalling that accounts for their pathogenic activity (fibrosis and muscle atrophy).
| Accession | PRJNA471921 |
| Data Type | Raw sequence reads |
| Scope | Multispecies |
| Grants | - "STAT3 signalling network in MuSCs as therapeutic target for DMD" (Grant ID 21084, The French Muscular Dystrophy Association)
- "San Diego Skeletal Muscle Research Center" (Grant ID P30 AR061303, National Institute of Arthritis and Musculoskeletal and Skin Diseases)
- "Signal-dependent switch of SWI/SNF by miRNAs & control of muscle stem cell fate" (Grant ID R01 AR052779, National Institute of Arthritis and Musculoskeletal and Skin Diseases)
- "Dystrophin signaling and the epigenetic landscape of human iPSC-derived muscles" (Grant ID R01 AR056712, National Institute of Arthritis and Musculoskeletal and Skin Diseases)
- "Role of STAT3 in muscle stem cell activation" (Grant ID R01 AR064873, National Institute of Arthritis and Musculoskeletal and Skin Diseases)
- "Role of muscle interstitial fibroadipogenic progenitors in the regulation of myofiber response to acute and pathological denervation" (Grant ID GR-2013-02356592, Italian Ministry of Health)
- "Generation of expandable, self-renewing muscle stem cells for Duchenne muscular dystrophy" (Grant ID TG2-01162, California's Stem Cell Agency)
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| Submission | Registration date: 17-May-2018
Sanford Burnham Prebys Medical Discovery Institute |
| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
|---|
| Sequence data |
| SRA Experiments | 12 |
| Other datasets |
| BioSample | 12 |