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Accession: PRJNA471547 ID: 471547

Altered mRNA splicing by mutant p53 activates oncogenic RAS in pancreatic cancer

Integrating transcriptomic analyses of both clinical PDAC and PDAC models, we identified that the most common neomorphic TP53 mutation (p53R175H) rewires RNA splicing promoting transcriptome-wide retention of cassette exons bearing cytosine(C)-rich sequences. More...
AccessionPRJNA471547; GEO: GSE114502
Data TypeTranscriptome or Gene expression
ScopeMultispecies
SubmissionRegistration date: 15-May-2018
Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
RelevanceUnknown
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments36
Other datasets
BioSample36
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes2333
SRA Data Details
ParameterValue
Data volume, Gbases715
Data volume, Tbytes0.30

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