See
Genome Information for Homo sapiens
Persistent bronchial dysplasia (BD) is associated with increased risk of developing invasive squamous cell carcinoma (SCC) of the lung. We hypothesized that differences in gene expression profiles between persistent and regressive BD would identify cellular processes that underlie progression to SCC. RNA expression arrays (Affymetrix Hu 1.0) comparing baseline biopsies from 32 bronchial sites that persisted/progressed to 31 regressive sites showed 395 differentially expressed genes (ANOVA, FDR/= histology score 4, FU >/= histology score 4)
Group 2 = Regressive bronchial dysplasia (BL >/= histology score 4, FU /= histology score 4)
Group 4 = Stable non-dysplasia (BL
| Accession | PRJNA471529; GEO: GSE114489 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens |
| Publications | Merrick DT et al., "Altered Cell-Cycle Control, Inflammation, and Adhesion in High-Risk Persistent Bronchial Dysplasia.", Cancer Res, 2018 Sep 1;78(17):4971-4983 |
| Submission | Registration date: 15-May-2018
Medicine/Medical Oncology, University of Colorado Anschutz Medical Campus |
| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
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| Publications |
| PubMed | 1 |
| PMC | 1 |
| Other datasets |
| GEO DataSets | 1 |
GEO Data Details| Parameter | Value |
|---|
| Data volume, Spots | 2094876 |
| Data volume, Processed Mbytes | 32 |
| Data volume, Supplementary Mbytes | 235 |