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Genome Information for Homo sapiens
The exon junction complex (EJC) deposited upstream of mRNA exon junctions during pre-mRNA splicing shapes the structure, composition and fate of all spliced mRNAs.
More...The exon junction complex (EJC) deposited upstream of mRNA exon junctions during pre-mRNA splicing shapes the structure, composition and fate of all spliced mRNAs. The goal of the study was to identify RNAs preferentially bound to EJC proteins RNPS1 and CASC3, which bind peripherally to the EJC core in a mutually exclusive manner. Both RNPS1 and CASC3 have been implicated in regulating mRNA translation and decay, and RNPS1 copy number variation is linked to intellectual disability and autism.
Less...| Accession | PRJNA471492 |
| Data Type | Transcriptome or Gene expression |
| Scope | Monoisolate |
| Organism | Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens |
| Grants | - "Regulation of RNA surveillance by the dynamic Exon Junction Complex" (Grant ID R01 GM120209, National Institute of General Medical Sciences)
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| Submission | Registration date: 15-May-2018
Ohio State University |
| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
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| BioSample | 1 |
No public data is linked to this project. Any recently released data that cites this project will be linked to it within a few days.