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Accession: PRJNA470938 ID: 470938

LATS kinase-mediated selective disruption of CTCF genomic binding (human)

See Genome Information for Homo sapiens
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66643 additional projects are related by organism.
We identified CTCF as a substrate of the LATS kinases. Under cellular stress conditions that activated LATS, CTCF was phosphorylated in a LATS-dependent manner and lost DNA-binding activity. More...
AccessionPRJNA470938; GEO: GSE114319
Data TypeEpigenomics
ScopeMultiisolate
OrganismHomo sapiens[Taxonomy ID: 9606]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens
PublicationsLuo H et al., "LATS kinase-mediated CTCF phosphorylation and selective loss of genomic binding.", Sci Adv, 2020 Feb;6(8):eaaw4651
SubmissionRegistration date: 10-May-2018
Jianrong Lu, Biochemistry and Molecular Biology, University of Florida
RelevanceMedical
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments4
Publications
PubMed1
PMC1
Other datasets
BioSample4
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes1
SRA Data Details
ParameterValue
Data volume, Gbases32
Data volume, Mbytes14465

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