Coccidioides immitis and Coccidioides posadassi are the causal agents of coccidioidomycosis or Valley fever. Morphologically both are identical but can be distinguished by numerous DNA polymorphisms. Both species belong to the order Onygenales which contain members that tend to associate with animals. Considering the following evolutionary relationships, the comparative genomic study investigated the hypothesis that Coccicioides have recently acquired its pathogenic phenotype. Onygenales relatives that recently diverged relative to the Coccidioides clade such as Uncinocarpus, Gymnoascus, and Crysosporium species have not been reported to cause disease but the more distantly related, Ajellomyces capsulatum, are known to be a mamalian pathogen.
| Accession | PRJNA46297 |
| Type | Umbrella Comparative genomics project (Subtype:Comparative genomics) |
| Organism | Onygenales[Taxonomy ID: 33183] Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; Eurotiomycetidae; Onygenales |
| Publications | Sharpton TJ et al., "Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives.", Genome Res, 2009 Oct;19(10):1722-31 |
| Submission | Registration date: 2-Mar-2010
- University of California, Berkeley- The University of Arizona - Seattle Biomedical Research Institute - University of Maryland School of Medicine - J. Craig Venter Institute - Broad Institute- The University of Texas at San Antonio - Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw - University of California at San Diego |
Project Data:
| Resource Name | Number
of Links |
|---|
| Sequence data |
| Nucleotide (total) | 378 |
| WGS master | 4 |
| Protein Sequences | 34212 |
| Publications |
| PubMed | 2 |
| PMC | 2 |
| Other datasets |
| BioSample | 4 |
| Assembly | 4 |
Onygenales encompasses the following 4 sub-projects:
| Project Type | Number of Projects |
Genome sequencingHighest level of assembly : Scaffolds Contigs Total |
3
1
4
|
|