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Accession: PRJNA344908 ID: 344908

Homo sapiens (human)

Clonal isolates of PC3 cells overexpressing CENPU

See Genome Information for Homo sapiens
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This project is a component of the Analysis of germline modifiers of aggressive prostate cancer using cross-species variation and systems genetics
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2 additional projects are components of the Analysis of germline modifiers of aggressive prostate cancer using cross-species variation and systems genetics.
66644 additional projects are related by organism.
We identified CENPU as prostate cancer metastases genes by analyzing QTL, transcript profiles and SNP associations with aggressive disease phenotypic traits in transgenic mice and human cohorts CENPU was futher validated as a metastases genes in vitro and in vivo utilizing prostate cancer cell lines overexpressing the gene, and we used microarray to analyze the changes in transcripts Overall design: Human prostate cancer cell line PC-3 were cloned with etither a control (empty) p-Lenti vector, or a p-Lenti vector containing the CENPU gene. More...
AccessionPRJNA344908; GEO: GSE87481
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismHomo sapiens[Taxonomy ID: 9606]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens
PublicationsWinter JM et al., "Mapping Complex Traits in a Diversity Outbred F1 Mouse Population Identifies Germline Modifiers of Metastasis in Human Prostate Cancer.", Cell Syst, 2017 Jan 25;4(1):31-45.e6
SubmissionRegistration date: 29-Sep-2016
NHGRI, NIH
RelevanceMedical
Project Data:
Resource NameNumber
of Links
Publications
PubMed1
PMC1
Other datasets
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Spots536170
Data volume, Processed Mbytes9
Data volume, Supplementary Mbytes88

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