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Genome Information for Rattus norvegicus
Understanding biological mechanisms that shape vulnerability to emotional dysfunction is critical for elucidating the neurobiology of psychiatric illnesses like anxiety and depression.
More...Understanding biological mechanisms that shape vulnerability to emotional dysfunction is critical for elucidating the neurobiology of psychiatric illnesses like anxiety and depression. To elucidate molecular
and epigenetic alterations in the brain that contribute to individual differences in emotionality, our laboratory utilized a rodent model of temperamental differences. Rats bred for low response to novelty (Low Responders, LRs) are inhibited in novel situations and display high
anxiety, helplessness, and diminished sociability compared to High Novelty Responder (HR) rats. Here, we utilized next-generation sequencing analysis of the methylome to reveal
the differentially methylated sites between these lines. Less...
| Accession | PRJNA344780 |
| Data Type | Epigenomics |
| Scope | Monoisolate |
| Organism | Rattus norvegicus[Taxonomy ID: 10116] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus; Rattus norvegicus |
| Grants | - "Neurodevelopmental Underpinnings of Rodent Anxiety and Depressive Behavior" (Grant ID R00 MH085859, National Institute of Mental Health)
- "Epigenetics, neurodevelopment, and emotional behavior" (Grant ID R01 MH105447, National Institute of Mental Health)
- "Dental Academic Research Training Program" (Grant ID T90 DE022736, National Institute of Dental and Craniofacial Research)
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| Submission | Registration date: 28-Sep-2016
Virginia Polytechnic Institute and State University |
| Relevance | Model Organism |
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