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1 additional project is a component of the Myc activation in breast cancer is due to p53-loss and sustains self-renewal of cancer stem cells.
Purpose: discover the downstream pathways and the mechanism of target activation by the p53:Myc axis in normal mammary and cancer stem cells
Methods: we performed ChIPseq experiments from NMuMG cells grown in adhesion under standard conditions
Results: the p53:Myc axis orchestrates its transcriptional response in mammary-epithelial cells via a dual and overlapping mechanism: i) a tightly controlled epistasis driven by p53 and executed by Myc, and ii) a co-operative double occupancy of their downstream effectors at different regulatory regions
Overall design: Examination p53 and Myc binding sites in murine mammary epithelial cells
| Accession | PRJNA343203; GEO: GSE87002 |
| Data Type | Epigenomics |
| Scope | Multiisolate |
| Organism | Mus musculus[Taxonomy ID: 10090] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus |
| Publications | Santoro A et al., "p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value.", Cell Rep, 2019 Jan 15;26(3):624-638.e8 |
| Submission | Registration date: 16-Sep-2016
Department of Experimental Oncology, European Institute of Oncology |
| Relevance | Model Organism |
Project Data:
| Resource Name | Number
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| Sequence data |
| SRA Experiments | 12 |
| Publications |
| PubMed | 1 |
| PMC | 1 |
| Other datasets |
| BioSample | 12 |
| GEO DataSets | 1 |