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Accession: PRJNA343202 ID: 343202

Mus musculus (house mouse)

Myc activation in breast cancer is due to p53-loss and sustains self-renewal of cancer stem cells (RNA-Seq)

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This project is a component of the Myc activation in breast cancer is due to p53-loss and sustains self-renewal of cancer stem cells
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1 additional project is a component of the Myc activation in breast cancer is due to p53-loss and sustains self-renewal of cancer stem cells.
47588 additional projects are related by organism.
Purpose: discover the downstream pathways and the mechanism of target activation by the p53:Myc axis in normal mammary and cancer stem cells Methods: we established mammosphere culture from normal and tumoral murine mammary glands and extracted RNA for expression analysis at passage 3 of the serial replating assay Results: These data demonstrate the existence of a set of 189 p53 and Myc common targets, which are implicated in the regulation of mitosis and are up-regulated in the ErbB2-tumor mammospheres, and suggest that these genes are crucial for the regulation of CSC numbers. More...
AccessionPRJNA343202; GEO: GSE87003
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismMus musculus[Taxonomy ID: 10090]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus
PublicationsSantoro A et al., "p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value.", Cell Rep, 2019 Jan 15;26(3):624-638.e8
SubmissionRegistration date: 16-Sep-2016
Department of Experimental Oncology, European Institute of Oncology
RelevanceModel Organism
Project Data:
Resource NameNumber
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Sequence data
SRA Experiments24
Publications
PubMed1
PMC1
Other datasets
BioSample24
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes7
SRA Data Details
ParameterValue
Data volume, Gbases136
Data volume, Mbytes93073

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