BioProject

Appetite is largely controlled by hypothalamic neurons. Variation near the TMEM18 gene has been significantly associated with increased body mass in multiple human genome-wide association studies. More...

Appetite is largely controlled by hypothalamic neurons. Variation near the TMEM18 gene has been significantly associated with increased body mass in multiple human genome-wide association studies. Accordingly, we ablated Tmem18 in the hypothalamus of mice and demonstrated this was sufficient to generate a metabolic phenotype. To investigate the molecular mechanisms through which Tmem18 influences feeding behaviour, we performed paired-end RNAseq on the Illumina platform in hypothalamic tissue from Tmem18 knockout and control mice????? This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute please see http://www.sanger.ac.uk/datasharing/ Less...