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ChIP-Seq experiments targeting H3K4me2, H3K4me3, H3K9ac, H3K27ac, H3K36me3 histone modifications have been performed in order to assess if SETBP1 binding to gDNA was associated with chromatin remodeling and to further characterize the mechanisms responsible for SETBP1-mediated transcriptional regulation
Overall design: n=10: 5 histone marks in 2 conditions: Empty vector and SETBP1-G870S
| Accession | PRJNA341460; GEO: GSE86328 |
| Data Type | Epigenomics |
| Scope | Multiisolate |
| Organism | Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens |
| Publications | Piazza R et al., "SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub.", Nat Commun, 2018 Jun 6;9(1):2192 |
| Submission | Registration date: 1-Sep-2016
Stem Cells and Neurogenesis, Neuroscience, Ospedale San Raffaele |
| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
|---|
| Sequence data |
| SRA Experiments | 10 |
| Publications |
| PubMed | 1 |
| PMC | 1 |
| Other datasets |
| BioSample | 10 |
| GEO DataSets | 1 |