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Genome Information for Homo sapiens
ERK activates ERG-mediated prostate cancer specific gene expression program by phopshorylation induced dissociation of PRC2 complex
Overall design: ChIP-Seq of transcription factor ERG and its co-repressor EZH2
RNA-seq of polyA selected RNA from RWPE1 cells expressing either empty vector, ERG-WT, ERG-S96A and ERG-S96E
| Accession | PRJNA340977; GEO: GSE86232 |
| Scope | Multiisolate |
| Organism | Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens |
| Publications | - Strittmatter BG et al., "Ras/ERK and PI3K/AKT signaling differentially regulate oncogenic ERG mediated transcription in prostate cells.", PLoS Genet, 2021 Jul;17(7):e1009708
- Kedage V et al., "Phosphorylation of the oncogenic transcription factor ERG in prostate cells dissociates polycomb repressive complex 2, allowing target gene activation.", J Biol Chem, 2017 Oct 20;292(42):17225-17235
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| Submission | Registration date: 30-Aug-2016
Indiana University |
| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
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| Sequence data |
| SRA Experiments | 20 |
| Publications |
| PubMed | 2 |
| PMC | 2 |
| Other datasets |
| BioSample | 20 |
| GEO DataSets | 1 |