When characterizing novel cell lines, we used SNP genotyping alignment to compare the tumor to the resulting cell line. In order to do this pairwise comparison as each cell model was developed, we added additional data from the GEO database during the normalization step. These data were either tumor DNA or cancer cell line DNA. These samples were not part of a matched pair and so genotype alignment was not reported for these samples.
The GEO Series and Sample numbers used for each sample grouping is as follows. Wood- Series: GSE21541; Samples: GSM533396, GSM533397, GSM533398, GSM533399, GSM533400, GSM533401, GSM533402, GSM533404, GSM533410. Ferry- Series: GSE16125; Samples: GSM403493, GSM403494, GSM403495, GSM403496, GSM403497, GSM403498, GSM403499, GSM403500, GSM403501. Jacket series 1: GSE15126; samples: GSM385517, GSM385518, GSM385519, GSM385520, GSM385521, GSM385522, GSM385523, GSM385524, GSM385525, GSM385526. Jacket series 2: GSE62407; Samples: GSM1526628, GSM1526648, GSM1526668. DF Series GSE39130; Samples: GSM956523, GSM956524, GSM956525, GSM956526, GSM956527, GSM956528.
Overall design: DNA was extracted from cell lines at several passages and the tumor tissue samples from which they were derived. Genotype was determined by SNP 250K Nsp.
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