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Accession: PRJNA335732 ID: 335732

Mus musculus (house mouse)

In vitro B cell activation by Th1 cells promotes the transcriptional programming of antibody-secreting cells, while B cell activation in presence of Th2 cells maintains the B cell identity transcriptional program

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To investigate the role of Th1 versus Th2 cell help on B cell activation and differentiation into B cell effectors and antibody secreting cells (ASCs), we utilized an in vitro culture system to activate B cells in the presence of Th1 or Th2 polarized CD4+ T cells. More...
AccessionPRJNA335732; GEO: GSE84948
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismMus musculus[Taxonomy ID: 10090]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus
PublicationsStone SL et al., "T-bet Transcription Factor Promotes Antibody-Secreting Cell Differentiation by Limiting the Inflammatory Effects of IFN-γ on B Cells.", Immunity, 2019 May 21;50(5):1172-1187.e7
SubmissionRegistration date: 28-Jul-2016
Microbiology, University of Alabama at Birmingham
RelevanceModel Organism
Project Data:
Resource NameNumber
of Links
Publications
PubMed1
PMC1
Other datasets
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Spots2038559
Data volume, Processed Mbytes46
Data volume, Supplementary Mbytes212

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