BioProject

AF1q/MLLT11 expression was significantly upregulated in CML patients and elevated AF1q expression was associated with disease progression. More...

AF1q/MLLT11 expression was significantly upregulated in CML patients and elevated AF1q expression was associated with disease progression. Enforced AF1q expression promoted cell survival, protected CML cells from IM treatment and increased engraftment of CML cells in vivo. We used microarrays in AF1q-overexpressing K562 cells and negative control cells to profile differentially expressed genes that might be involved in AF1q regulation. Overall design: K562 cells infected with lentiviruses harboring AF1q were prepared in triplicates: AF1q-1,2,3, meanwhile negative control cells as RFP-1,2,3. 106 cells from each group were used for RNA extraction and hybridization on Affymetrix microarrays. Less...