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Genome Information for Plasmodium falciparum
The emergence and spread of resistance to antimalarial drugs has been and continues to be a significant challenge in the fight against malaria.
More...The emergence and spread of resistance to antimalarial drugs has been and continues to be a significant challenge in the fight against malaria.The goal of this study was to compare Sanger sequencing and next generation sequencing (NGS) for a previously-reported and well-characterized case of malarone treatment failure in a U.S. patient with malaria. Here, we illustrate the utility of using NGS for early detection of a critical mutation associated with antimalarial drug (Malarone) treatment failure. In contrast, Sanger sequencing failed to detect the same mutation as early as NGS.
Less...| Accession | PRJNA290960 |
| Data Type | Targeted Locus (Loci) |
| Scope | Monoisolate |
| Organism | Plasmodium falciparum[Taxonomy ID: 5833] Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania); Plasmodium falciparum |
| Submission | Registration date: 25-Jul-2015
Center for Disease Control and Prevention |
| Relevance | Medical |
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