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Accession: PRJNA290332 ID: 290332

Mus musculus (house mouse)

Expression data from isogenic Pten WT or KO mouse T-ALLs treated with DBZ or DMSO

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This project is a component of the Expression data from isogenic Pten WT or KO mouse T-ALLs
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1 additional project is a component of the Expression data from isogenic Pten WT or KO mouse T-ALLs.
47588 additional projects are related by organism.
To investigate the underlying mechanisms mediating resistance to NOTCH inhibition in Pten-null T-ALL tumor cells we performed gene expression profiling of isogenic Pten-positive and Pten-deleted leukemia lymphoblasts after acute treatment with DBZ in vivo. More...
AccessionPRJNA290332; GEO: GSE71087
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismMus musculus[Taxonomy ID: 10090]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus
Publications
  • Sanchez-Martin M et al., "Synergistic antileukemic therapies in NOTCH1-induced T-ALL.", Proc Natl Acad Sci U S A, 2017 Feb 21;114(8):2006-2011
  • Herranz D et al., "Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia.", Nat Med, 2015 Oct;21(10):1182-9
SubmissionRegistration date: 20-Jul-2015
ICG, Columbia University
RelevanceModel Organism
Project Data:
Resource NameNumber
of Links
Publications
PubMed2
PMC2
Other datasets
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Spots541212
Data volume, Processed Mbytes9
Data volume, Supplementary Mbytes45

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