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Accession: PRJNA290313 ID: 290313

Homo sapiens (human)

CRISPR-Cas9 combinatorial KO of epigenetic regulators in human ovarian cancer cells

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66643 additional projects are related by organism.
We sequenced polyA mRNA from OVCAR8-ADR-Cas9 cells in which one or two of 3 epigenetic regulators (BRD4, KDM4C, KDM6B) had been knocked out to examine how global gene expression was affected and evaluate potential synergistic effects at a molecular level. More...
AccessionPRJNA290313; GEO: GSE71074
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismHomo sapiens[Taxonomy ID: 9606]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens
PublicationsWong AS et al., "Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.", Proc Natl Acad Sci U S A, 2016 Mar 1;113(9):2544-9
SubmissionRegistration date: 20-Jul-2015
Decibel Therapeutics
RelevanceMedical
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments12
Publications
PubMed1
PMC1
Other datasets
BioSample12
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes8
SRA Data Details
ParameterValue
Data volume, Gbases16
Data volume, Mbytes10126

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