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Genome Information for Mus musculus
Alternative RNA processing plays an essential role in shaping cell identity and connectivity in the central nervous system (CNS).
More...Alternative RNA processing plays an essential role in shaping cell identity and connectivity in the central nervous system (CNS). The vast cellular diversity in the CNS implicates differential regulation of RNA processing in various cell types. However, in vivo study of transcriptome-wide RNA regulation in a cell-type specific manner has been a challenge given the cellular and molecular complexity of the CNS. Here, we generated bacterial artificial chromosome (BAC)-transgenic mice expressing motoneuron-specific tagged Nova2 protein, and used cross-linking immunoprecipitation (CLIP) to study RNA regulation specifically in spinal cord motor neurons. For a subset of motor neuron messenger RNAs (mRNAs), we identified differential RNA regulation otherwise obscured in whole spinal cord CLIP, highlighting the value of defining RNA processing regulation at single cell type resolution.
Less...| Accession | PRJNA290215 |
| Data Type | Raw sequence reads |
| Scope | Multiisolate |
| Organism | Mus musculus[Taxonomy ID: 10090] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus |
| Submission | Registration date: 17-Jul-2015
Rockefeller University |
| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
|---|
| BioSample | 14 |
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