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Accession: PRJNA289886 ID: 289886

Mus musculus (house mouse)

Effect of IRE1a and XBP1 knockdown on gene expression in primary mouse keratinocytes expressing an HRas oncogene

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47588 additional projects are related by organism.
IRE1a is a critical modulator of the unfolded protein response. Its RNAse activity generates the mature transcript for the XBP1 transcription factor and also degrades other ER associated mRNAs in a process termed Regulated IRE1a Dependent mRNA Decay or RIDD. More...
AccessionPRJNA289886; GEO: GSE70899
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismMus musculus[Taxonomy ID: 10090]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus
PublicationsBlazanin N et al., "ER stress and distinct outputs of the IRE1α RNase control proliferation and senescence in response to oncogenic Ras.", Proc Natl Acad Sci U S A, 2017 Sep 12;114(37):9900-9905
Grants
  • "IRE1a: a Conditional Tumor Suppressor" (Grant ID R01 CA197942, National Cancer Institute)
SubmissionRegistration date: 14-Jul-2015
Veterinary and Biomedical Sciences, The Pennsylvania State University
RelevanceModel Organism
Project Data:
Resource NameNumber
of Links
Publications
PubMed1
PMC1
Other datasets
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Spots421740
Data volume, Processed Mbytes6
Data volume, Supplementary Mbytes102

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